Lion's Mane Extract
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Lion's Mane Extract falls short.
Single-ingredient Lion's Mane (500mg fruiting-body extract per capsule) -- the easiest to clear customs as a single-ingredient supplement. Ships from the US; the brand's shipping-methods page (checked 2026-09-28) describes worldwide international shipping with no GCC state excluded. ISO-certified in-house lab publishes a Certificate of Analysis per batch, which may assist with import documentation for SFDA (Saudi Arabia), MOHAP (UAE), or other GCC-state MOH queries. Caffeine-free; vegan per the brand's product page; capsule shell material not stated (checked 2026-10-07).
What it does
Nootropics Depot Lion's Mane Extract is a single-ingredient supplement providing standardised Hericium erinaceus fruiting body extract at 500mg per capsule. Nootropics Depot operates an ISO-certified in-house testing laboratory and publishes a Certificate of Analysis (CoA) for every batch. For GCC buyers: as a single-ingredient product, it presents a simpler customs profile than multi-ingredient stacks; the publicly available CoA can be provided to SFDA, MOHAP, or relevant MOH authorities if documentation is requested. The product is caffeine-free, is vegan per the brand's product page (capsule shell material not stated, checked 2026-10-07), and ships from the US.
How it works
Lion's Mane extracts raised Nerve Growth Factor (NGF) in cell and mouse studies, but in one cell study the fruiting body's hericenones did not (Mori 2008); the compound shown to reach the brain, erinacine A, comes from the mycelium and was tested in rats (Tsai 2021). We found no human trial that measured NGF. NGF promotes neuronal survival, axon growth, and maintenance of neurons in the hippocampus and cortex -- the regions responsible for learning and memory. Nootropics Depot uses a standardised fruiting body extract rather than mycelium.
What to expect
Lion's Mane is a long-game supplement. Pilot trials reported small acute effects within 1–2 hours. In a trial in adults with mild cognitive impairment, scores improved after 16 weeks of 3g a day and fell again within 4 weeks of stopping (Mori 2009). At the label's 1–2 capsules a day (500–1,000mg), this product reaches at most the low end of the pilot-trial doses (1–1.8g) and a third of the 3g a day used by Mori 2009. For best results, take consistently every day. This product is best combined with a multi-ingredient stack (e.g. Mind Lab Pro already contains Lion's Mane) rather than used as a standalone primary supplement.
Hero ingredients
- Lion's Mane (standardised fruiting body extract)
Who it's for
- ISO lab -- publishes CoA per batch
- Standardised fruiting body
- Best value single-ingredient
Who should skip
- Single ingredient only
- Verify import status with your local customs -- some GCC states restrict certain supplements
Dosing audit
| Ingredient | Label | Clinical | Status |
|---|---|---|---|
| Lion's Mane fruiting body extract (1:1) | 500mg | 1000-1800mg/day | ✕ Under |
Ingredient quality
Number and quality of evidence-graded ingredients. Trademarked extracts and standardized actives raise this score.
Dosing vs. clinical evidence
The share of ingredients with a reference dose on our ingredient pages whose label-stated daily amount meets that page's minimum. Amounts the label hides (blend shares) or states on a different basis count as not met; ingredients with no reference page are listed but not scored.
Formula transparency
Full disclosure of every ingredient at its exact dose. Proprietary blends are scored as opaque.
Value for money
Cost per month relative to per-serving clinical doses delivered. Cheaper products with underdoses score lower.
Brand trust
Brand reputation, third-party testing, refund track record, and Trustpilot signal across multiple years.
How the score is computed
Each pillar is weighted by editorial importance. Weights are constant across every brand we audit — they're not adjusted to favour any particular product.
- Ingredient quality25%
- Dosing vs. clinical evidence30%
- Formula transparency20%
- Value for money15%
- Brand trust10%
2,715 verified reviews
We don't embed cherry-picked quotes here. Trustpilot is the canonical source — the score above feeds into our Trust pillar.
Read all 2,715 reviews on Trustpilot →What the vendor’s site says
Quoted word for word from the vendor’s own pages. Terms change, so check them before you buy.
Returns
Nootropics Depot accepts returns of unopened product within 30 days of its delivery date.
Per support.nootropicsdepot.com (opens in new tab), checked
Our affiliate cookie
We don't earn a commission on this product; we have no affiliate deal for it. Our scores and rankings follow our published methodology; commissions do not influence them.
Buying in the Gulf
- Local price
- ≈ $9.99/month
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Health disclaimer
Dietary supplements sold in Saudi Arabia are regulated by the Saudi Food and Drug Authority (SFDA); in the UAE, general food supplements are regulated by Dubai Municipality while products making medicinal or therapeutic claims require marketing authorisation from the Emirates Drug Establishment (EDE, ede.gov.ae), which now handles drug registrations previously processed through the Ministry of Health and Prevention (MOHAP). Many GCC consumers prefer Halal-certified supplements; capsule shells (gelatin vs HPMC vegetable cellulose) are a meaningful differentiator. We surface Halal-certifying authority where verifiable and never fabricate certifications. This page is editorial, not medical advice. Always consult a qualified healthcare professional before starting any supplement.